Birch bark’s betulin may contribute to metabolic benefits

March 30th, 20120 Comments »
BioMed | 1/5/2011

An ingredient found in abundance in birch bark appears to have an array of metabolic benefits, according to new studies in animals that are reported in the January issue of Cell Metabolism, a Cell Press publication. In mice, the compound known as betulin lowered cholesterol, helped prevent diet-induced obesity, and improved insulin sensitivity.

Betulin-treated mice were also more resistant to developing atherosclerotic plaques in their arteries. Betulin works by targeting so-called sterol regulatory element-binding proteins (SREBPs), transcription factors that are known to be important for activating the expression of genes involved in the biosynthesis of cholesterol, fatty acids, and triglycerides. ”Our study shows that the SREBP pathway is a good target for several metabolic diseases,” said Bao-Liang Song of the Shanghai Institutes for Biological Sciences. ”We also identify a leading compound.” In the new study, Song and his colleagues went in search of a compound that might act directly on SREBP. That chemical screen turned up betulin as a top contender. They then confirmed in cells that betulin lowered the activity of genes that are normally switched “on” by SREBP.  It also lowered lipid levels within cells.

Song’s team then treated mice on a high-fat, Western diet with betulin, the cholesterol-lowering statin known as lovastatin, or a placebo (saline) for 6 weeks. Compared to placebo, both drugs led the mice to gain less weight on the high-fat diet, though by different means. Betulin caused the animals to burn more calories while lovastatin appeared to reduce the amount of lipid taken up from the diet. Further investigations showed that betulin also lowered lipid levels in blood, liver, and fat tissue.

Betulin also made the animals more sensitive to insulin. Mice with a mutation that makes them prone to develop atherosclerosis showed fewer plaques when treated with either lovastatin or betulin. ”Betulin has several major metabolic effects,” Song said.

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